NAD+ TRANSPATCH
Ingredients:
YOUNGVIBE NAD+ Transpatch 1200mg / 2000mg
Benefits of NAD+ TRANSPATCH：
"Rapid Activation": Instant Effect, Direct Cellular Delivery
Utilizing iontophoresis technology, NAD+ molecules are broken down into micro-ions for enhanced transdermal penetration, entering the bloodstream 5x faster* than oral supplementation!
"Ultra Absorption": 95% Bioavailability, Visible Anti-Aging Results
Our NAD+ TRANSPATCH bypasses biological barriers to achieve 95% absorption! Experience accelerated metabolism, reduced fatigue, and visibly brighter, firmer skin—youthful radiance from within!
"Effortless Comfort": Discreet Wear, Zero Lifestyle Disruption
The ultrathin, breathable patch becomes virtually invisible upon application—perfect for workouts or workdays. Needle-free and painless, even for sensitive skin. Seamless daily integration makes anti-aging elegantly simple!
What Is NAD+ TRANSPATCH?
Advances in modern medicine have made health management simpler and more comfortable. The YOUNG VIBE NAD+ TRANSPATCH utilizes advanced transdermal iontophoresis technology—no needles, no IV drips required. Simply apply the patch to your skin, and it delivers high-concentration NAD+ molecules slowly and continuously to deep tissues over 4 hours, providing efficient energy replenishment and cellular repair.
Technical Overview
Intended Use
TransPatch products are intended to be used for the administration of soluble salts into the body for medical purposes as an alternative to hypodermic injection. It is intended to be used in situations when it is desirable to avoid the pain or danger that may be imposed by needle insertion and injection.
For purposes of skin safety, TransPatch products have been designed for use with low levels of DC current. They are designed to administer medication slowly and continuously over a period of several hours.
Principles of Operation
Iontophoresis is a process which utilizes bipolar electric fields to propel molecules across intact skin into underlying tissue. Positively charged ions in solution are transferred from a positive (+) chamber, while negatively charged ions in solution are transferred from a negative (-) chamber. Ions are transferred to the body at a rate proportional to the magnitude of the current flow between electrodes. The total number of molecules transferred during iontophoresis is related to the total electric charge utilized; one equivalent weight of molecules is delivered by one Faraday of charge (96,500 coulombs, where one coulomb = 1 amp-second). Conventional units of delivery dosage in iontophoresis are milliamp-minutes, which are calculated as [milliamps of current applied] x [time of application in minutes].
Iontophoresis is now commonly used by caregivers to deliver water soluble anti-inflammatory medications locally into sub-acute or acute inflammations, as an alternative to syringe-and-needle injection (ref. 1). Studies have shown iontophoresis has penetrated medication to depths of at least 1 cm (ref. 1).
TransPatch
TransPatch products are disposable single-use devices, with a self-contained power source. Both the negative and positive chambers are contained in the TransPatch. In use, the TransPatch can simultaneously deliver both negatively and positively charged compounds by placing each compound in the relevant chamber.
A cross section of a representative TransPatch is shown below.
Coatings on the TransPatch electrodes provide a potential of approximately one volt, which induces a current flow when the patch is applied to the body. Additional potential may be provided by an integrated 3V battery to give a total potential of four volts. Current flow is induced when the patch is applied to the body. Electrode coatings are gradually consumed during use, and current flow is suspended when the coatings are depleted. Precise, known amounts of coatings are deposited on the electrode surfaces during manufacture.
On the electrodes:
A zinc coating is oxidized at the positive (anodic) electrode surface:
Zn = Zn(++) +2e(-) E° = -0.76
A silver chloride coating is reduced at the negative (cathodic)
electrode surface:
AgCl +c(-) = Ag + Cl(-) E°=0.22
ΔΕ = 0.98 volts
Test Results: Patch-to-Patch Reproducibility
For a typical manufactured IontoPatch lot, electrode capacity is determined by immersing the electrode in a 10% NaCl solution and discharging it against a counter-electrode with a 10 Ohm resistor placed in series within the circuit. Current flow is recorded until it falls to 1% of the peak value.
Results:
Number of Patches Tested: 200
Labeled Capacity: 80mA-min
Measured Capacity mean: 81.4mA-min
Measured Capacity sd: 3.8 mA-min
Measured Capacity cv: 4.7%
Delivery Rate: Theoretical considerations
With TransPatch products, the power source potential will induce a current flow between electrode chambers according to Ohm's Law:
V = IR; where V = voltage (volts), I = current (amps), and R = resistance (ohms)
The electrical properties of skin are complex and most biological systems are nonlinear and therefore change with time (ref 2). Consequently, individual skin resistance and delivery rate for the lontoPatch will vary, and are dependent on factors such as skin cleanliness, skin hydration, and the number of sweat pores at the delivery site. Delivery time is dependent upon individual patient skin resistance. For the average patient, dosage delivery for the lontoPatch 80 and SP products will be complete in approximately 14 hours and the rate of drug delivery will be substantially reduced after 24 hours. For the average patient, dosage delivery for the lontoPatch STAT product will be complete in approximately 4 hours and the rate of drug delivery will be substantially reduced after 6 hours. For the average patient, dosage delivery for the IontoPatch Extra Strength" product will be complete in approximately 8 hours and the rate of drug delivery will be substantially reduced after 12 hours.
Delivery Rate: Test Results
TransPatches built to 40 mA-min capacity were loaded with 1% NaCl solution and placed on differing locations on human subjects. Current flow was monitored over the course of 4 hours, with the following
Results:
Number of IontoPatches tested: 8
Average Current Flow: 0.09 mA
Range: 0.05-0.16 mA
From this data, the average current flow for TransPatch, which has a potential of four volts, is estimated to be 0.36 mA. From this data, the average current flow for ITransPatch , which has a potential of four volts and a series resistance of approximately 4kOhms, is estimated to be 0.26 mA.
Delivery Amount: Theoretical Considerations
Charge transferred during iontophoresis can be attributed to many factors, including delivery of soluble ions intended, delivery of 'competing' ions of similar charge, and oppositely charged ions moving in reverse direction. Delivery efficiency can be defined as the percentage of current flow attributable to the ion intended to be delivered.
Delivery Amount: Test Results
Delivery of a model negatively charged compound was evaluated using both in-vitro (laboratory) and in-vivo (on human volunteer subjects) conditions. In both cases, iontophoretic delivery was determined by subtracting passive delivery (e.g. transfer in the absence of current flow) from total delivery (transfer in the presence of current flow).
In-Vitro Delivery
In-vitro testing was conducted using glass diffusion cells, with battery electrodes immersed in receiver and donor compartments separated by an ultrafiltration membrane. Total charge transfer was limited to 80 mA-minutes, and was measured by monitoring current flow with a data acquisition station connected in-line with the batteries.
In-Vivo Delivery
In-vivo delivery was determined by loading 80 mA-min TransPatches with an exactly known amount of model compound, placing them on volunteer subjects for 24 hours, and measuring residual content of the model compound by extraction from the patch after removal from the subjects.
Results:
N
Average Iontophoretic Delivery (mg)
Range (mg)
Measured sd (mg)
In-Vitro
4
0.8
0.6-1.0
0.2
In-Vivo
5
1.1
0.8-1.7
0.4
Warnings and Precautions
Use all appropriate precautions related to the compound intended for delivery. Acetic Acid (the non-ionic acid form of Sodium Acetate) and Iodine (the non-ionic form of Iodide) are not recommended for use with the TransPatch. Since Acetic Acid and Iodine are non-ionic, they will not be delivered by iontophoresis and they may cause skin irritation.
Contraindication: TransPatch is contraindicated for use over damaged or denuded skin, and for treatment around the orbital region of the head.
Warning: Patients should be asked about their history of drug allergies or sensitivities. Patients should be advised to remove the TransPatch STAT after 6 hours. Iontophoresis can cause skin irritation and burn including redness under the pads. Skin discoloration or hyper-pygmentation, caused by the adhesives and/or some medications, is possible. These conditions will generally resolve over time, once iontophores is discontinued. IontoPatch products should not be worn during MRI procedures.
Patients should be advised to report any undue burning or pain at once during treatment. The treatment should be paused, the area under the electrodes should be inspected, and any necessary corrective actic should be taken before resuming treatment. Do not wrap tightly or apply excessive pressure for long periods of time.
Important: To minimize skin irritation, patients should be instructed to remove the patch slowly using soap and water in the shower or bath. Patients should also be advised that adhesive tapes such as the tape used in the lontoPatch may occasionally irritate the skin resulting in slight changes in skin color that will return to normal over time.
pH and Current Density Effects: Theoretical Considerations
Iontophoretic systems, when improperly administered, have been known to cause skin damage and pain (ref 3). With many conventional iontophoresis systems, inert carbon, platinum, or gold electrodes are used, which result in electrolysis of water at the electrode surface as current flows. Water electrolysis produces hydrogen gas and high pH at the cathode, and oxygen gas and low pH at the anode. These pH changes, and high current densities are considered the cause of skin injury associated with iontophoretic treatment (ref 1). Buffers are sometimes added to iontophoretic patches to mitigate pH change, but these salts compete with medication delivery and reduce delivery efficiency. The IontoPatch electrodes do not electrolyze water, require no buffer salts, and use current densities which are below those associated with skin damage (ref 3).
Test Results: pH Change With Use of the TransPatch
To test the effect of IontoPatch electrodes and battery discharge on the pH of solutions contained in the patch, an in-vitro apparatus was set-up with anionic and cationic chambers separated by a 1 M KCl agarose salt bridge. pH before and after battery discharge of a 40 mA-min patch was measured using a pH meter calibrated with NIST traceable standards. For comparison purposes, the same apparatus and unbuffered solutions were tested using a galvanostat and conventional carbon electrodes.
Test Solution: Unbuffered 1% NaCl in each chamber
Positive Chamber
Negative Chamber
IontoPatch System
pH initial/final
6.65/6.61
6.62/6.95
Conventional System
pH initial/final
6.65/2.04
6.67/11.45
Test Results: Current Density
High current density levels are also considered as a cause for skin damage, with recommended current densities to be below 1 mA per square inch to avoid harmful effects (ref 1,3). TransPatches built to 40 mA- min capacity were loaded with 1% NaCl solution and placed on differing locations on human subjects. The highest current density measured was compared to maximum current densities recommended in literature references (ref 1,3). The expected maximum current densities for the IontoPatch STAT and TransPatch Extra Strength are calculated from the TransPatch study.
TransPatch 0.58 mA/in
0.58 mA/in
Expected Maximum Current Density:
References
1. C. Costello, A. Jeske: Iontophoresis: Applications in Transdermal Medications Delivery. Physical Therapy 75: 104-113,1995.
2. P. Prausnitz: The effects of electrical current applied to skin: A review for transdermal drug delivery. Advanced Drug Delivery Reviews 18: 395-425,1996.
3 . L. Li, R. Scudds: Iontophoresis: An Overview of the Mechanisms and Clinical Application. Arthritis Care and Research 8:51-61,1995.
Operation Process
Step 1
Begin by trimming body hair in the target area.
Step 2
Wash the area with soap and water, then thoroughly dry the skin. Do not use alcohol swabs, as they may cause excessive dryness and irritation.
Step 3
After diluting NAD+, apply it to the anode (positive) side of the patch. Then apply saline solution to the cathode (negative) side.
Step 4
Peel off the patch’s protective film and apply it to the desired area.
Step 5
Gently press around the edges of the patch to secure it in place. Avoid pressing the center electrodes immediately after application, as this may displace the liquid onto the adhesive surface, reducing adhesion.
